PHENOTYPIC SCREENING

shells

   PHENOTYPE  •

“The set of observable characteristics of an organism resulting
from
the interaction of its genotype with the environment”

Oxford Dictionary

It describes the combination of an organism’s biochemical,
physiological, morphological and behavioral characteristics

•  PHENOTYPIC SCREEN  

A type of screening test used in biological research or drug discovery to assess phenotypic alterations resulting from both the desired or undesired effect
of a substance (e.g, small molecules, proteins, RNAi) on a cell or organism

 

 

While we use the same words, our definitions, understanding and interpretation may differ.

 multiple fingerprints

  OUR DEFINITION 

We quantitatively measure compound effect on multiple parameters simultaneously to capture the interplay between various physiological mechanisms and biological pathways, cell by cell. Our embrace of population heterogeneity within the high cell numbers we measure, delivers a statistical robustness, sensitivity and resolution that is unique to our approach.

 •   SCIENCE   •   DATA   •   ANALYSIS   •   RESULTS   •

Our multiplexed, human cell-based, phenotypic screening applications, utilizing flow cytometry, provide a unique understanding of how integrated biological networks, targets and signaling pathways interact to define a specific biological response to a substance. Each response creates a unique fingerprint which in turn can be compared for similarity to a database of fingerprints from marketed therapeutics, failed drugs and known toxins. An information rich approach to de-risking your drug discovery process.

To enable this comparison, we concurrently developed a state-of the-art machine learning algorithm for automated analysis of similarity. Our screens are robust, our biological assessments have depth, our information is rich, our analysis is sophisticated; however, it is how we combine this system based approach that is unique. Our definition:

SYSTEMETRIC®

A system based approach to multi-parametric analysis